Arene oxides can participate in substitution reactions with the nucleoside components of DNA. Once substituted, the nucleoside can no longer fit into the DNA double helix and the genetic code will not be properly transcribed, which can lead to mutations that cause cancer. Cancer results when cells lose their ability to control their growth and reproduction. Draw arrows to show how the 2'-deoxyguanosine nucleoside below can react with an arene oxide to produce a substituted nucleoside product. Please draw in a generic base and conjugate acid to allow you to fully describe the reaction mechanism with arrows and assume this is a concerted reaction. (4 points) NH N NH NH N 'N ??. per q- ** OH HOH H HOH HT